Cushing Syndrome: Causes, Symptoms and Treatment 

Cushing Syndrome is a complex medical condition that affects numerous individuals worldwide. This article will provide a comprehensive overview of Cushing Syndrome, its causes, symptoms, diagnosis, treatment, prevention, and what it’s like living with this condition. 

What is Cushing Syndrome? 

Cushing Syndrome, also known as hypercortisolism, is a rare hormonal disorder characterized by an excess of cortisol, a hormone produced by the adrenal glands. This excess cortisol can lead to a range of health issues. 

Who is affected by Cushing Syndrome? 

Cushing Syndrome can affect people of all ages, although it is more commonly diagnosed in adults aged 20 to 50 years. It is more prevalent in women than in men. 

How common is Cushing Syndrome? 

Cushing Syndrome is considered rare, with an estimated incidence of 10 to 15 cases per million people per year. However, the actual prevalence may be higher due to underdiagnosis. 

What’s the difference between Cushing Syndrome and Cushing Disease? 

Cushing Syndrome refers to the condition caused by excessive cortisol in the body, which can have various underlying causes. In contrast, Cushing Disease specifically results from a benign pituitary tumor that stimulates the overproduction of cortisol. 

Is Cushing Syndrome fatal? 

Cushing Syndrome itself is not typically fatal. However, if left untreated or poorly managed, it can lead to severe complications that may be life-threatening. 

Symptoms and Causes 

What causes Cushing Syndrome? 

Cushing Syndrome can have several causes, including: 

  • Excessive Cortisol Production: This can result from an adrenal gland tumor, excessive use of corticosteroid medications, or overproduction of adrenocorticotropic hormone (ACTH) by the pituitary gland. 
  • Adrenal Tumors: Benign or malignant tumors on the adrenal glands can lead to increased cortisol production. 
  • Ectopic ACTH Production: Some tumors outside the pituitary and adrenal glands can produce ACTH, triggering cortisol overproduction. 

Is Cushing Syndrome genetic? 

While Cushing Syndrome is not directly inherited, some individuals may have a genetic predisposition that makes them more susceptible to developing the condition. 

What are the symptoms of Cushing Syndrome? 

The symptoms of Cushing Syndrome can vary widely but often include: 

  • Weight gain, especially in the abdomen and face 
  • High blood pressure 
  • Muscle weakness 
  • Mood swings 
  • Skin changes, such as thinning and easy bruising 
  • Increased thirst and urination 
  • Fatigue 

How long does Cushing Syndrome last? 

The duration of Cushing Syndrome varies depending on its underlying cause and the effectiveness of treatment. It can be a temporary condition or persist for years if not managed properly. 

Does Cushing Syndrome cause shortness of breath? 

Yes, shortness of breath can be a symptom of Cushing Syndrome, particularly when excess weight gain and fluid retention put pressure on the chest and lungs. 

Does Cushing Syndrome cause osteoporosis? 

Cushing Syndrome can increase the risk of osteoporosis due to the loss of bone density that often accompanies this condition. 

Does Cushing Syndrome cause hypokalemia? 

Yes, hypokalemia, a condition characterized by low potassium levels in the blood, can be a complication of Cushing Syndrome. 

Diagnosis and Tests 

How is Cushing syndrome diagnosed? 

Diagnosing Cushing Syndrome involves a thorough medical evaluation, including: 

  • Physical examination 
  • Blood tests to measure cortisol levels 
  • Imaging tests, such as CT or MRI scans 
  • Urine tests to assess cortisol secretion 

What tests will be done to diagnose Cushing syndrome? 

To confirm a Cushing Syndrome diagnosis, your healthcare provider may perform tests such as the dexamethasone suppression test, midnight cortisol test, or ACTH stimulation test. 

Management and Treatment 

How is Cushing syndrome treated? 

The treatment of Cushing Syndrome depends on its underlying cause. It may involve: 

  • Surgery: Removal of adrenal tumors or pituitary tumors. 
  • Medications: In cases where surgery is not an option, medications may be prescribed to reduce cortisol production. 
  • Radiation therapy: For tumors that cannot be surgically removed. 


How can I reduce my risk of or prevent Cushing syndrome? 

Preventing Cushing Syndrome primarily involves avoiding excessive use of corticosteroid medications and managing underlying conditions that may lead to cortisol overproduction. 

Outlook / Prognosis 

What can I expect if I have Cushing syndrome? 

With early diagnosis and appropriate treatment, individuals with Cushing Syndrome can experience significant improvement in their symptoms and overall quality of life. 

How long does Cushing syndrome last? 

The duration of Cushing Syndrome can vary from a few months to years, depending on the cause and treatment effectiveness. 

Can Cushing syndrome get worse? 

If left untreated or if the underlying cause is not managed, Cushing Syndrome can lead to worsening symptoms and complications. 

Living With 

What’s it like living with Cushing syndrome? 

Living with Cushing Syndrome can be challenging due to the physical and emotional symptoms. However, with proper medical care and support, individuals can lead fulfilling lives. 

When should I see my healthcare provider? 

If you suspect you may have Cushing Syndrome or are experiencing its symptoms, it is crucial to seek medical attention promptly for diagnosis and treatment. 

What questions should I ask my healthcare provider? 

  • What is the underlying cause of my Cushing Syndrome? 
  • What treatment options are available for my specific case? 
  • Are there any potential complications I should be aware of? 
  • How can I manage the side effects of treatment? 
  • Are there any lifestyle changes or dietary recommendations to follow? 
  • How frequently should I have follow-up appointments? 


In conclusion, Cushing Syndrome is a challenging medical condition characterized by excess cortisol production. Understanding its causes, symptoms, and treatment options is crucial for those affected by it. With timely diagnosis and appropriate medical care, individuals with Cushing Syndrome can lead fulfilling lives despite the challenges it presents. 

Originally published by Gainswave  at January 24, 2024. Updated 01.2024.
Medically reviewed by David Cunningham, MD, GAINSWave’s Clinical Advisor.
Reviewed by y Dr. Kendrick Heywood, an accomplished medical professional, GAINSWave’s Clinical Advisor.


Cushing Syndrome can often be effectively managed and controlled with treatment, but a complete cure may not always be possible. 

While Cushing Syndrome itself is not typically fatal, its complications can be life-threatening if left untreated. 

Stress alone is not a direct cause of Cushing Syndrome, but it can exacerbate symptoms in individuals already affected by the condition. 

Yes, there are support groups and online communities where individuals with Cushing Syndrome can connect, share experiences, and find emotional support. 

Yes, children can develop Cushing Syndrome, although it is less common in pediatric populations. 

While it may not be entirely preventable, you can reduce your risk by avoiding excessive corticosteroid use and managing related conditions. 

Get men's health tips delivered straight to your inbox:

Related Posts

Recent posts

Scroll to Top